Add the ketchup, dark brown sugar, apple cider vinegar, Worcestershire sauce, hot sauce, dry mustard, garlic powder, onion powder, kosher salt, and coarse ground pepper in a small saucepan, whisking together to combine.

Heat the combined mixture over medium heat until it begins to boil, reduce heat immediately to low. Continue to cook, occasionally stirring, as the mixture simmers on low heat until sauce thickens, in about 15 minutes.